Injuries are already piling up just a month into the 2025 NFL season. These maladies are creating conundrums for NFL teams and fantasy football managers alike.
Week 4 alone saw two top wide receivers – Malik Nabers and Tyreek Hill – suffer significant knee injuries that will knock them out for the remainder of the season.
Additionally, players like Bucky Irving, Lamar Jackson and Brock Purdy came out of their action banged up. That has left many fantasy managers wondering just how healthy their teams will be in Week 5.
With bye weeks kicking in this week, it will be especially important for fantasy managers to keep an eye on their injured players and be vigilant about adding potential replacements.
Here’s what to know about the injuries to major fantasy producers across the NFL.
Fantasy football injury updates: Week 5
RB Bucky Irving, Tampa Bay Buccaneers
Bucs coach Todd Bowles acknowledged Monday that Irving has an injury that concerns him following the team’s 31-25 loss to the Philadelphia Eagles.
Tampa Bay has not yet provided a concrete update on Irving’s status, but NFL Network’s Mike Garafolo reports Irving is ‘still gathering medical opinions’ on an ankle or foot injury. The running back’s status for Week 5 is ‘up in the air’ as a result.
QB Lamar Jackson, Baltimore Ravens
Jackson exited the Ravens’ loss to the Kansas City Chiefs after suffering a hamstring injury. He was spotted on the sideline wearing a wrap on his leg, and did not return to action.
Coach John Harbaugh hasn’t yet provided a timeline for Jackson, but Brian Wacker of The Baltimore Sun reports the star quarterback is expected to miss 2-3 weeks because of the injury.
The Ravens have a bye in Week 7, so they could consider holding Jackson out until after that to give him extra time to recover from the soft-tissue injury.
QB Jayden Daniels, Washington Commanders
Dan Quinn provided an update about Daniels’ status at a media availability Monday.
‘He had a strong workout here Saturday, and we’ll take today and tomorrow and work out his practice plan,’ Quinn said of Daniels. ‘We’ll go through the whole process with him this week, medically, how he feels, how he practices, and give you the updates Wednesday, as I know them.’
Daniels has missed the last two weeks because of a knee injury. The Commanders have gone 1-1 with backup quarterback Marcus Mariota starting in his place.
QB Brock Purdy, San Francisco 49ers
Purdy missed Weeks 2 and 3 before returning to the action against the Jacksonville Jaguars. However, he aggravated his toe injury during the game, throwing his status for San Francisco’s ‘Thursday Night Football’ game against the Los Angeles Rams into doubt.
49ers general manager John Lynch said in his weekly spot on KNBR on Tuesday he wasn’t sure Purdy would be able to play.
‘I think he’s listed as questionable, and I think that’s a true reflection of where he’s at right now,’ Lynch said.
Purdy said during a Tuesday media availability his toe felt a lot better than it did after the Week 1 game. However, he also said he would not be able to play if the game was played Tuesday, giving him just two days to recover.
Purdy was listed as a non-participant on the 49ers practice reports both Monday and Tuesday.
WR Ricky Pearsall, San Francisco 49ers
Like Purdy, Pearsall is expected to be questionable for Thursday’s game after failing to practice Monday and Tuesday. The second-year receiver is dealing with a knee injury he aggravated after banging his leg into the ground trying to make a catch on the sideline in the second half of the team’s loss to the Jaguars.
Kyle Shanahan said after Sunday’s game Pearsall was dealing with a minor PCL injury.
WR Terry McLaurin, Washington Commanders
McLaurin missed the Commanders’ Week 4 game because of a quad injury. Quinn was asked about his status, along with those of fellow pass-catching weapons Noah Brown and John Bates, and provided the following update Monday:
‘I would say we’re all trending in the right space on there,’ Quinn said of the trio. ‘We will have a better update on Wednesday in terms of practice planning and that, but arrows are heading up for a number of the guys.’
WR Tyreek Hill, Miami Dolphins
Hill’s surgery went well, according to his agent Drew Rosenhaus, and the goal is for the veteran receiver to return to the field in 2026.